Only ever keep one or two types of ammunition on you for very particular weapons. Break down as much of your ammunition as you like into its components and sell everything else. Since ammunition has weight in Hardcore mode you’ll want to approach this in a more intelligent manner.
Lastly once you have Solar Powered you will need less healing items during the day. Also having Adamantium Skeleton makes it so that you need less limb recovery. The most important ones are probably Pack Rat and Strong Back as these let you carry extra weight.
Each Perk fills a particular niche: Hunter makes it easier to get food by killing enemies, Educated gives extra skill points and so on. This is probably one of the most fun character types to play as you really feel like you’re living the life of a Mojave Wastelander.
